Cardiovascular and Cerebrovascular Events in the Randomized, Controlled Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT)
نویسنده
چکیده
Funding: This work was supported by the National Institute on Aging (NIA), grant U01 AG15477. NIA collaborators participated in the design and conduct of the study and in the interpretation and review of the study results. Celecoxib and the matching placebo were provided by Pfizer, and naproxen sodium and the matching placebo were provided by Bayer Healthcare; Pfizer and Bayer did not participate in the design, conduct, or analysis of the study, but did provide comments on the manuscript.
منابع مشابه
Cardiovascular and Cerebrovascular Events in the Randomized, Controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
OBJECTIVES The Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) was designed to evaluate the conventional NSAID naproxen sodium and the selective COX-2 inhibitor celecoxib for primary prevention of Alzheimer's dementia (AD). On 17 December 2004, after the Adenoma Prevention with Celecoxib (APC) trial reported increased cardiovascular risks with celecoxib, the ADAPT Steering Commit...
متن کاملADAPT: The Wrong Way to Stop a Clinical Trial
In an accompanying article published in PLoS Clinical Trials, the Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) Research Group report the cardiovascular outcomes from their study [1]. The circumstances surrounding the termination of ADAPT were unusual and provide an important lesson for all clinical trialists, demonstrating the importance of following rigorous procedures for pr...
متن کاملThe use of nonsteroidal anti-inflammatory drugs (NSAIDs): a science advisory from the American Heart Association.
Recent clinical trial data have raised questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. In September 2004, Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib) because of an increased risk of heart attack and stroke. In early December 2004, ...
متن کاملUse of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association.
Clinical trial data have prompted questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. Since the 2005 publication of a Science Advisory on the use of nonsteroidal antiinflammatory drugs (NSAIDs) by the American Heart Association,1 several important events have o...
متن کاملUse of Nonsteroidal Antiinflammatory Drugs
Clinical trial data have prompted questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. Since the 2005 publication of a Science Advisory on the use of nonsteroidal antiinflammatory drugs (NSAIDs) by the American Heart Association,1 several important events have o...
متن کامل